Screening and isolation of penicillinase inhibitor, KA-107.
نویسندگان
چکیده
It is known that penicillin resistance of bacteria is mainly caused by the inactivation of penicillin by penicillinase derived from such strains. We have developed a screening procedure for penicillinase inhibitors. Several microorganisms were found to produce such inhibitors, and from the culture filtrate of Streptomyces gedanensis ATCC 4880 a penicillinase inhibitor, named KA-107, was isolated. The characteristics of this inhibitor were revealed by an in vitro test by using penicillinase derived from penicillin resistant Staphylococcus aureus, FS-1277. When KA-107 was used in combination with penicillin-G, ampicillin, d- or l-phenethicillin, the growth inhibitory activity of these penicillins was maintained.
منابع مشابه
In vitro and in vivo activity of penicillinase inhibitor KA-107 against Staphylococcus aureus FS-1277.
The activities of penicillinase inhibitor, KA-107 extracted from culture filtrates of Streptomyces gedanensis ATCC 4880, were studied by using penicillin-resistant S. aureus FS-1277 and by means of in vitro and in vivo tests.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 4 3 شماره
صفحات -
تاریخ انتشار 1973